.png)
01
Mechanisms of Tau Pathology
Dissecting how abnormal tau drives neuronal dysfunction and degeneration in tauopathies - from phosphorylation and aggregation through to synaptic failure and cell death.
02
Drosophila Disease Models
Harnessing fruit fly genetics to model tauopathy in vivo, enabling rapid screening and mechanistic dissection not possible in mammalian systems alone.
03
Drug Discovery & Diagnostics
Translating mechanistic insights into disease-modifying drug targets and patient-specific diagnostic tools for earlier diagnosis and better stratification.
Our Approach
Why Drosophila?
Fruit flies share ~75% of human disease genes. Their short lifespan, powerful genetic toolkit, and amenability to high-throughput screening make them an exceptional platform for neurodegeneration research.
We combine behavioural assays, confocal imaging, qPCR, and biochemical approaches with cutting-edge methods through our interdisciplinary collaborations