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Publications

Welcome to the publications page of our lab! Here, we showcase our latest research and contributions to the scientific community. From exploring the complexities of ageing and neurodegeneration to innovative drug discovery methods using Drosophila melanogaster, our work aims to push the boundaries of knowledge and drive impactful solutions. Browse through our studies to learn more about our findings and ongoing endeavours.

2026

The Drosophila wing is a high-throughput and versatile screening tool for Tau-mediated disease mechanisms and drug discovery
Miguel Ramirez-Moreno, Amber S. Cooper, Tianshun Lian, Jie Liu, Seyedehleila Abtahi, Efthimios M.C. Skoulakis, Lovesha Sivanantharajah, Douglas Watt Allan and Amrit Mudher

2025

Are we missing a trick by not exploiting fruit flies in inflammation-led drug discovery for neurodegeneration?
Ray Price, Miguel Ramirez-Moreno, Amber Cooper, Rachita Singh, Yee Ming Khaw, Annastasiah Mudiwa Mhaka, Lovesha Sivanantharajah and Amrit Mudher

Examining the vulnerability of adult neuron subtypes to tau-mediated toxicity in Drosophila
Lovesha Sivanantharajah, Amrit Mudher & David Shepherd 

Optical biomarkers for Alzheimer's disease prediction in a heterogenous clinical cohort
George Devitt, Sofia Michopoulou, Angus Prosser, Boyd CP Ghosh, Amritpal Mudher, Christopher Kipps and Sumeet Mahajan

Classification of Alzheimer’s disease in a mixed clinical cohort using biofluid Raman spectroscopy
​George Devitt, Sofia K. Michopoulou, Latha Kadalayil, Niall Hanrahan, Angus Prosser, Boyd Ghosh, Amrit Mudher, Christopher M. Kipps and Sumeet Mahajan 

Enhancing the specificity of Raman spectroscopy by using multiple lasers
George Devitt, Niall Hanrahan, Simon Lane, Sofia K. Michopoulou, Angus Prosser, Latha Kadalayil, Jordi Mayneris-Perxachs, Jonathan Swann, Boyd Ghosh, Amrit Mudher, Christopher Kipps, Sumeet Mahajan

A Novel Spectral Barcoding and Classification Approach for Complex Biological Samples Using Multiexcitation Raman Spectroscopy (MX-Raman)
George Devitt, Niall Hanrahan, Miguel Ramírez Moreno, Amrit Mudher, and Sumeet Mahajan

2024

Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in Drosophila
Amber Cooper, Bradley Richardson, Eva Ruiz Ortega, Yongrui Zhang, Ben Batchelor, Aarya Vaikakkara Chithran, Jie Liu, Tianshun Lian, Miguel Ramírez Moreno, Benjamin Boehme, Leila Abtahi, George Devitt, Lovesha Sivanantharajah, Efthimios M. C. Skoulakis, Douglas W. Allan, and Amritpal Mudher 

A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer’s disease and other tauopathies.
Anthony Aggidis, George Devitt, Yongrui Zhang, Shreyasi Chatterjee, David Townsend, Nigel J. Fullwood, Eva Ruiz Ortega, Airi Tarutani, Masato Hasegawa, Amber Cooper, Philip Williamson, Ayde Mendoza-Oliva, Marc I. Diamond, Amritpal Mudher, David Allsop

How do neurons age? A focused review on the aging of the microtubular cytoskeleton
Brad Richardson, Thomas Goedert, Shmma Quraishe, Katrin Deinhardt, Amritpal Mudher

2023

Human Tau aggregates are permissive to protein synthesis-dependent memory in Drosophila tauopathy models.
Ergina Vourkou, Eva D. Rouiz Ortega, Sumeet Mahajan, Amrit Mudher and Efthimios M.C. Skoulakis

Tau-mediated axonal degeneration is prevented by activation of the WldS pathway
Katy Stubbs , Ben Batchelor , Lovesha Sivanantharajah , Megan Sealey , Miguel Ramirez-Moreno , Eva Ruiz , Brad Richardson , Victor H Perry , Tracey A Newman , Amritpal Mudher

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